Services on Demand
Journal
Article
Indicators
- Cited by SciELO
- Access statistics
Related links
- Similars in SciELO
Share
Gaceta médica de México
On-line version ISSN 2696-1288Print version ISSN 0016-3813
Abstract
AGUILAR-ROMERO, Estefanía et al. Prognostic variables in patients with thick melanomas. Analysis of 362 cases. Gac. Méd. Méx [online]. 2021, vol.157, n.2, pp.215-219. Epub June 23, 2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.20000332.
Background:
Studies on prognostic factors in melanoma are based on Caucasian populations, with a predominance of thin melanomas (Breslow <3 mm). Mexican patients show a predominance of thick melanomas (Breslow ≥ 3 mm).
Objective:
To identify factors associated with the prognosis of patients with thick melanomas.
Material and methods:
The prognostic influence of clinicopathological factors was analyzed in 362 thick melanomas.
Results:
The Breslow median was 7 mm, 271 (74.9 %) patients had acral melanoma and 49 (13.5 %) nodular melanoma. The 56.6 % of patients were found in clinical stage [CS] III), 269 (74.3 %) had ulceration, and 15 (4.1 %) had positive margins. The variables associated with lower overall survival [OS] were CS (p < 0.001), Breslow (p = 0.044), ulceration (p = 0.004), mitosis (p < 0.001) and margin < 2 cm (p < 0.001). In the multivariate analysis, the factors influencing OS were CD, mitosis, and the surgical margin.
Conclusions:
In patients with thick melanomas, OS is influenced by a positive margin, mitosis and CS.
Keywords : Melanoma; Breslow; Acral melanoma; Mitotic index; Prognosis.