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Gaceta médica de México
On-line version ISSN 2696-1288Print version ISSN 0016-3813
Abstract
REYES-MUNOZ, Enrique et al. Nutritional supplements in the prevention of gestational diabetes mellitus: Evidence-based lessons learned. Gac. Méd. Méx [online]. 2020, vol.156, suppl.3, pp.43-50. Epub Oct 25, 2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.m20000437.
Introduction:
Gestational diabetes mellitus (GDM) affects between 5 and 40% of pregnant women. Recently different interventions with nutritional supplements have been evaluated for prevention of GDM.
Aim:
To perform a synthesis of the evidence on the efficacy of nutritional supplements (myo-inositol, probiotics, and vitamin D) in the prevention of GDM.
Methods:
A systematic search in PubMed and Cochrane library was performed, including systematic reviews of randomized clinical trials (RCTs), published in English or Spanish until May 2020, using the keywords: "prevention", "gestational diabetes", "hyperglycemia and pregnancy", "supplementation", "probiotics", "myo-inositol" and "vitamin D".
Results:
10 systematic reviews that met the inclusion criteria were analyzed. Myo-inositol supplementation compared to placebo decreased the incidence of GDM (RR: 0.44 [0.27-0.87]; five RCTs), low quality of evidence. Although the supplementation with vitamin D or probiotics during pregnancy could reduce the incidence of GDM the evidence is limited.
Conclusions:
Myo-inositol supplementation is effective for prevention of GDM in high-risk women. Supplementation with vitamin D or probiotics probably decreases the incidence of GDM.
Keywords : Gestational diabetes; Pregnancy; Probiotics; Myo-inositol; Vitamin D.