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Gaceta médica de México
On-line version ISSN 2696-1288Print version ISSN 0016-3813
Abstract
ROMERO-LOPEZ, Zaira et al. Prevalence of chronic obstructive pulmonary disease in patients diagnosed with HIV without prior antiretroviral treatment. Gac. Méd. Méx [online]. 2020, vol.156, n.4, pp.283-289. Epub May 27, 2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.m20000407.
Introduction:
Chronic obstructive pulmonary disease (COPD) is the most prevalent respiratory problem in the world. Patients with human immunodeficiency virus (HIV) infection have a higher prevalence of smoking and recurrent lung infections and are at higher risk of COPD.
Objective:
To determine the prevalence of COPD in HIV-diagnosed patients referred to an infectious diseases hospital.
Method:
Individuals with HIV infection without previous or ongoing antiretroviral treatment, with chronic respiratory symptoms, with or without a history of exposure for the development of COPD were included. Pre- and post-bronchodilation spirometry, high-resolution computed tomography, viral load determination and CD4 count were carried out. Spirometry measurements were compared with Wilcoxons test.
Results:
Sixty-six HIV-diagnosed patients, with a mean age of 31.5 years were included; 64 were males and two females. The prevalence of COPD was 7.6 %. The group with obstruction had a lower CD4 count (27.3 versus 225.9) and higher viral load (165,000 versus 57,722), in comparison with the group without obstruction. A positive correlation was observed between lower viral load and higher forced expiratory volume in 1 second/forced vital capacity ratio.
Conclusion:
HIV-positive patients with a lower CD4 count and a higher viral load show a decrease in spirometry values.
Keywords : Respiratory diseases; Chronic obstructive pulmonary disease; Bronchodilation; Human immunodeficiency.