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Gaceta médica de México

On-line version ISSN 2696-1288Print version ISSN 0016-3813


SANTILLAN-DOHERTY, Patricio  and  COLEGIO DE BIOETICA et al. Considerations on genetic engineering: regarding the birth of twins subjected to gene edition. Gac. Méd. Méx [online]. 2020, vol.156, n.1, pp.53-59.  Epub May 26, 2021. ISSN 2696-1288.

In this essay, the bioethical implications of the recent genetic manipulation in human embryos with CRISPR-Cas9 to eliminate the CCR5 gene and the birth of a pair of discordant twin girls are analyzed. The experiment was disseminated via social media. The main bioethical flaws identified include the justification of the model, the informed consent process and the lack of disclosure of evident conflicts of interest. The consequences of the experiment on the life of the twins that were born were not properly evaluated, such as the impact on their autonomy, the alleged benefits to be received and the future risks of harm during their lifetime. Having manipulated the germ cell line, the effects on their future offspring were not considered. This type of actions negatively affects the way society conceives science. Genetic engineering should be reserved to the basic experimental context or as clinical research for the correction of known serious diseases of genetic origin under strict regulatory and bioethical supervision and using a gradualist approach in accordance with the advances of gene editing techniques.

Keywords : Gene editing; CRISPR-Cas9; Bioethics.

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