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Gaceta médica de México

On-line version ISSN 2696-1288Print version ISSN 0016-3813

Abstract

HERNANDEZ-DA MOTA, Sergio et al. Classification of fundus autofluorescence abnormal patterns in diabetic macular edema. Gac. Méd. Méx [online]. 2019, vol.155, n.5, pp.458-462.  Epub July 01, 2021. ISSN 2696-1288.  https://doi.org/10.24875/gmm.m20000332.

Introduction:

Patients with diabetic macular edema can develop fundus autofluorescence alterations; thus far, these alterations have been more widely studied with scanning or confocal laser systems.

Objective:

To describe and classify fundus autofluorescence abnormal patterns in patients with diabetic macular edema using the fundus autofluorescence system with a flash camera.

Method:

Observational, retrospective, cross-sectional, descriptive study. Fundus autofluorescence digital images of non-comparative cases with untreated diabetic macular edema, obtained and stored with a flash camera system, were assessed. Inter-observer variability was evaluated.

Results:

37 eyes of 20 patients were included. Lens opacity was the most common cause of inadequate image quality. Five different fundus autofluorescence patterns were observed: decreased (13%), normal (40%), single-spot hyper-autofluorescent (17 %), multiple-spot hyper-autofluorescent (22 %) and plaque-like hyper-autofluorescent (8 %). The kappa coefficient was 0.906 (p = 0.000).

Conclusions:

Different fundus autofluorescence phenotypic patterns are observed with flash camera systems in patients with diabetic macular edema. A more accurate phenotypic classification could help establish prognostic factors for visual loss or for the design of clinical trials for diabetic macular edema.

Keywords : Fundus autofluorescence; Diabetic macular edema; Diabetic retinopathy.

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