Abstract

LUNA-PALENCIA, Gabriela Rebeca; CORREA-BASURTO, José  and  VASQUEZ-MOCTEZUMA, Ismael. El ácido valproico como agente sensibilizador al tratamiento anticáncer. Gac. Méd. Méx [online]. 2019, vol.155, n.4, pp.417-422.  Epub July 01, 2021. ISSN 2696-1288.  https://doi.org/10.24875/gmm.18004749.

Valproic acid is an antiepileptic drug with more than 50 years of clinical use. In the past decade, its anticancer effects were discovered. Analyses in groups of patients who used this drug for years have shown that it decreases the frequency of head and neck cancer. Recent studies show the anticancer effect of combining valproic acid with chemotherapy, biological therapy and antioxidant systems inhibitors, with exceptional results. In this review, we analyze the metabolism of valproic acid and its application against cancer.

Keywords : Valproic acid; Human cancer therapy; Epigenetic therapy; Histone deacetylase inhibitors.

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