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Gaceta médica de México
On-line version ISSN 2696-1288Print version ISSN 0016-3813
Abstract
CONDE-FERRAEZ, Laura et al. Infección por citomegalovirus humano en neonatos de un hospital público de Mérida, Yucatán. Gac. Méd. Méx [online]. 2019, vol.155, n.4, pp.336-342. Epub July 01, 2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.19003736.
Introduction:
Human cytomegalovirus (HCMV) is recognized as the most common cause of congenital viral infection, which can occur as a result of primary infection, reinfection or infection reactivation in the pregnant woman and be the cause of delay in neuronal development and sensorineural hearing loss in the neonate.
Objective:
To identify CMVH infection in newborns by real-time polymerase chain reaction (RT-PCR) and cell culture.
Method:
Observational, cross-sectional, retrospective study with oral swab samples from 362 neonates born within a 10-month period in a public hospital of Mérida, Yucatán. RT-PCR was carried out for the detection of HCMV. Fibroblast primary cell culture was obtained from human foreskin tissue to isolate the virus. Only positive cases were followed.
Results:
A prevalence of HCMV infection of 0.86 % was found by RT-PCR. No virus was isolated with cell culture. In the follow-up visits, sensory health and neurodevelopment were adequate.
Conclusion:
The prevalence of HCMV infection is similar to that of worldwide reports, and only was detected by RT-PCR. Asymptomatic infection detected 12-14 h after birth had no long-term health consequences.
Keywords : Cytomegalovirus; Newborns; Congenital infection; Real time PCR; Cell culture.