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Gaceta médica de México

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MENDEZ-SANCHEZ, Nahum; CHAVEZ-TAPIA, Norberto C.  and  URIBE-ESQUIVEL, Misael. Ghrelin and the gastro-hypothalamic axis. Gac. Méd. Méx [online]. 2006, vol.142, n.1, pp.49-58. ISSN 0016-3813.

Obesity is currently considered one of the most important diseases worldwide due to its high morbidity and mortality rates. The mechanisms involved in the control of satiation, body weight and energy expenditure has led to the discovery of new hormones that participate in the gastric-hypothalamic axis in charge of regulating satiation and other obesity-related processes. Ghrelin a novel hormone secreted mainly by gastric tissue, has shed some light on this mechanism. It is a hormone that regulates satiation and body weight by centrally mediated mechanisms, involving neuropeptide Y and Agouti associated proteins. The present review focuses on some important physiological aspects of this hormone.

Keywords : Appetite; ghrelin; neuropeptide Y; satiation; obesity.

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