Abstract

CUENCA, John A.; SCHETTINO, Marissa G.; VERA, Ketty E.  and  TAMARIZ, L. Esteban. Chimeric antigen receptor T-cell therapy: A narrative review of the literature. Gac. mex. oncol. [online]. 2022, vol.21, n.1, pp.17-25.  Epub Mar 14, 2022. ISSN 2565-005X.  https://doi.org/10.24875/j.gamo.21000181.

Chimeric antigen receptor T cell (CAR-T) therapy is one of the most advanced forms of immunotherapy. It is based on the genetic modification of T lymphocytes through the infection by a retrovirus that serves as the vector. The genetic information is translated into the production of a chimeric membrane receptor, which is directed specifically against a tumor protein. These T lymphocytes proliferate and generate an inflammatory response targeting tumor cells, in many cases achieving a curative response. This new strategy has shown promising results in the treatment of malignancies refractory to conventional cytotoxic chemotherapies, especially in acute lymphoid leukemia and certain types of Non-Hodgkin’s lymphoma. This review of the literature synthesizes the principles of the genetically engineered CAR-T cells, the anti-tumoral mechanism, clinical application, and its adverse events.

Keywords : Chimeric antigen receptor therapy; Adoptive immunotherapy; Adoptive cell therapy; T-Lymphocytes; Hematology; Genetic engineering.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )