Introduction:

Neutrophils are one of the most important cellular components of innate immunity because these cells are rapidly recruited to sites of infection and can eliminate pathogens by multiple methods. In different entities from which sepsis disables neutrophils improve their antimicrobial properties by releasing neutrophils extracellular traps (NET), constituted by chromatin, histones and granular proteins, a process that is known by NETosis.

Objective:

The objective of this paper is to review current concepts related to the underlying mechanisms of the formation of NETs, as well as the beneficial and harmful effects of them.

Conclusions:

The dysregulation of NETosis caused by sepsis can have detrimental effects that cause inflammation, thrombosis and multi-organ failure.

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