Relevance:

The multisystemic presentation of tuberous sclerosis complex combined with the histologic findings of collision angiomyolipoma and clear cell renal cell carcinoma is a rare entity in the medical literature.

Clinical implications:

Angioembolization results in fewer postoperative complications of ileus, pain, or infection, and its utility in the present case was important for facilitating the approach during nephrectomy and reducing the risk for intraoperative bleeding.

Conclusions:

The present case report provides a description of Wunderlich syndrome in a patient with tuberous sclerosis complex and the histopathologic diagnosis of a collision tumor, consisting of angiomyolipoma and clear cell renal cell carcinoma. Angioembolization of the right renal artery was performed before nephrectomy, reducing the risk for intraoperative bleeding.

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