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Acta médica Grupo Ángeles
Print version ISSN 1870-7203
Abstract
CASTELLANOS CHAVEZ, Joel et al. Palonosetron compared with ondansetron and dexamethasone in the control of nausea and vomiting in the postoperative period of laparoscopic cholecystectomies. Retrospective cohort study. Acta méd. Grupo Ángeles [online]. 2021, vol.19, n.1, pp.52-56. Epub Jan 31, 2022. ISSN 1870-7203.
Postoperative nausea and vomiting (PONV) in laparoscopic cholecystectomy surgery is common. The use of ondansetron and dexamethasone (GOD) and palonosetron (GP) is very prevalent.
Objective:
To compare the effectiveness in the control of the PONV.
Material and methods:
We conducted a comparative study of two retrospective cohorts of 62 patients each with elective cholecystectomy surgery; one with GOD prophylaxis and another with GP. The risk of PONV was assessed by the Apfel scale. The PONVs were studied in the 24 hours post-recovery of the anesthesia.
Results:
There were no differences regarding gender, pre-anesthetic assessment (ASA) and risk of PONV between the groups. 12.9% (8/62) of the patients in the GOD group had nausea against those in the GP group (p = 0.003). No patient presented post-operative vomiting (p = 1.00). In the GOD group, six patients required pharmacological rescue (9.6%) compared to none in the GP (p = 0.014). There were no side effects in either group.
Conclusion:
The use of palonosetron evidenced better control of nausea, but both prophylactic strategies controlled post-operative vomiting.
Keywords : Palonosetron; ondansetron; nausea; vomiting; laparotomy; cholecystectomy; postoperative nausea and vomiting.
