Abstract

BARRERA-MENDEZ, Felipe et al. Propiconazole nanoencapsulation in biodegradable polymers to obtain pesticide-controlled delivery systems. J. Mex. Chem. Soc [online]. 2019, vol.63, n.1, pp.50-60.  Epub July 02, 2019. ISSN 1870-249X.  https://doi.org/10.29356/jmcs.v63i1.564.

The nanoencapsulation of pesticides in biodegradable polymers confers several advantages to conventional agrochemicals, such as protection against losses due volatilization and degradation of the active ingredient, as well as the augment of water dispersion, allowing for their application on crops without requiring the use of organic solvents that could harm the user and the environment. These characteristics could enhance the productivity, reducing both costs and environmental pollution. In this work the propiconazole fungicide, forming part of a commercial formulation as well as in its pure state, was encapsulated using as carriers the biodegradable polymer poly lactic acid (PLA) and the biodegradable co-polymer poly (lactic-co-glycolic) acid, all with the aim of generate systems of controlled release of fungicide to augment the efficiency of the treatments of the Fusarium dieback disease. The most efficient system obtained presented nanospheres of 146.28 nm and an encapsulation efficiency over 42%. The antifungal activity tests showed that the use of this nanoencapsulated fungicide system enhances the growth inhibition percentage in 5%, obtaining a formulation that presents good dispersion in water without the need of organic emulsifier agents. The release profile test showed that while the commercial formulation dialyzed 50 and 90% of the propiconazole in approximately 5 and 30 hours, respectively, it took the nanoencapsulated propiconazole almost twice as much time to dialyze the same percentage of load, effectively prolonging the availability of the fungicide without diminishing the antifungal activity.

Keywords : Nanooencapsulation; Propiconazole; Fungicide; Fusarium; Emulsification and solvent evaporation.

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