Abstract

FLORES-ALDAMA, Marco J.  and  FLORES-SILVA, Fernando D.. Neurotoxicity of calcineurin inhibitors: Tacrolimus. Rev. mex. neurocienc. [online]. 2019, vol.20, n.6, pp.284-287.  Epub Mar 22, 2022. ISSN 2604-6180.  https://doi.org/10.24875/rmn.19000073.

At the beginning of this century, calcineurin inhibitors, especially tacrolimus, were the treatment of choice for immunosuppression in solid organs. It is known that in recent years, the incidence of renal and hepatic transplants has increased up to 15%, and therefore, a compelling reason why immunosuppression treatment is more relevant to reduce rejection, morbidity, and mortality rates. Although the systemic complications of the use of calcineurin inhibitors are known, there is still little information on its neurotoxic effects; however, a prevalence in up to 28% is estimated with a broad spectrum of clinical and radiological manifestations. The relevance of this work lies in describing the phenomenon of neurotoxicity, its clinical and radiological manifestations, risk factors, and management.

Keywords : Neurotoxicity; Tacrolimus; Tremor; Transplant.

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