Abstract

ROWENSZTEIN, Hernán; BERLIN, Valeria  and  SCRIGNI, Adriana. Risk factors associated to nonsyndromic craniosynostosis. Bol. Med. Hosp. Infant. Mex. [online]. 2010, vol.67, n.1, pp.37-43. ISSN 1665-1146.

Background. Craniosynostosis is a congenital malformation caused by premature closure of one or more cranial sutures. The treatment is early surgery for aesthetic reasons and to prevent increased intracranial pressure, neurological developmental disorders and optic atrophy. The aim of the present study was to investigate risk factors for craniosynostosis. Methods. We designed a case/control study from January 2000-December 2005 in a third-level hospital. Statistical analysis was done using SPSS statistical program. Results. Included in the study were 59 cases and 177 controls. Males are more commonly affected than females (86%). Diagnosis was made at an average of 5.8 months. Related to type of craniosynostosis, synostosis of the sagittal sutures is the most common form of this malformation. Antibiotics consumption during pregnancy was a risk factor for craniosynostosis (OR =5.13 95% Cl 1.57-17.1, P =0.001). Parental occupation and, more specific, cold-storage plant work, was statistically significant (OR =12.8 95% Cl 1.37-307, P =0.014. There was no relationship between labor and puerperium and craniosynostosis. Conclusion. The present study supports an association between antibiotic consumption and parental occupation and development of craniosynostosis.

Keywords : craniosynostosis; antibiotics; risk factors.

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