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TIP. Revista especializada en ciencias químico-biológicas
Print version ISSN 1405-888X
Abstract
GARCIA-ROJAS, Vanessa et al. Use of 13C-glucose breath test to assess treatment adherence in nutritional intervention trials. TIP [online]. 2021, vol.24, e359. Epub Apr 17, 2023. ISSN 1405-888X. https://doi.org/10.22201/fesz.23958723e.2021.359.
Objective:
To validate the use of the 13C-glucose breath test to assess nutritional treatment adherence.
Methods:
A pilot study was conducted on eleven adults. A snack made of soybean/corn-starch was enriched with U-13C-glucose. The participants were divided in three groups that consumed the snack in different periods for two weeks (A=14 days, B=10 days and C=6 days). Breath samples were collected daily to analyse the δ 13C values with isotope-ratio mass spectrometry.
Results:
AUC (area under the curve) median of δ 13C values of group A was higher than group C (p = 0.029); differences were found when combining groups, A and B medians, comparing them with group C (p = 0.038). A negative association was found between AUC δ13C values and treatment intensity (Spearman rho = -0.708; p = 0.015). A cut-off ≤ 3.78 identifies subjects with less than 70% accomplishment of the treatment with 100% specificity and 86% sensitivity.
Conclusions:
The 13C-glucose breath test suggests a good diagnostic performance to assess treatment adherence.
Keywords : 13C-glucose breath-test; nutritional treatment compliance; treatment adherence; 13C; soy-based snack.