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Ginecología y obstetricia de México
Print version ISSN 0300-9041
Abstract
LOPEZ-RIOJA, MJ et al. Preimplantation genetic testing for aneuploidies PGT-A: Results of the transition between different technologies. Ginecol. obstet. Méx. [online]. 2018, vol.86, n.2, pp.96-107. ISSN 0300-9041. https://doi.org/10.24245/gom.v86i2.1634.
OBJECTIVE
Communicate the results obtained from the analysis of the preimplantation genetic study for aneuploidy in two centers of assisted reproduction in Mexico in a period of three years, using two differentmolecular techniques.
MATERIALS AND METHODS
Descriptive, retrospective study, which reports the blastocysts PGT-A results, over 2014-2017, in two Fertility Centers (Ciudad de México and Guadalajara). The embryos where divided in two groups by their molecular techniques studied: 76 by a-CGH and 328 by NGS
RESULTS
We analyzed a total of 404 blastocysts from 129 patients (mean age 39 ± 4 years), with two different molecular techniques: a-CGH and NGS. The euploid embryos percentage was 33%. The numerical aneuploidies were the most frequent. Up to the ending of the study, 69% of the euploid embryos had been transferred. The implantation rates were 78% for those analyzed by NGS and 57% with a-CGH.
CONCLUSIONS
The implantation rate was bigger with the PGT-A by NGS. Our results reported, supports a single embryo transfer policy. It is important to recognize the challenges of new technologies and the need for more sensitive molecular techniques.
Keywords : Genetic testing; Aneuploidies; In vitro fertilization; Blastocysts; Implantation; Single embryo transfer.
