Abstract

SILVEIRA, Márcia Victória; LOPES, Toni Jefferson  and  ROSA, Gilber Ricardo. N-arylation of the imidazole via Cul: A tutorial for optimization of a catalytic system through of experimental design. Educ. quím [online]. 2017, vol.28, n.1, pp.44-50. ISSN 0187-893X.  https://doi.org/10.1016/j.eq.2016.10.001.

This work deals the development of a catalytic system for the N-arylation of imidazole with CuI through experimental design. 1,10-Phenanthroline (bidentate ligand) was used and proved to be efficient in the coupling of iodo- and bromoarenes with imidazole. Thus, the article presented here is intended to serve as a tutorial for optimization of new catalytic systems and may be applied as a lowcost practical class for chemistry undergraduate students.

Keywords : Imidazole; CuI; Experimental design.

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