Abstract

CARRILLO ESPER, Raúl et al. Urinary neutrophil gelatinase-associated lipocalin as early biomarker of severe acute kidney injury in Intensive Care. Rev. Asoc. Mex. Med. Crít. Ter. Intensiva [online]. 2016, vol.30, n.1, pp.10-16. ISSN 0187-8433.

Objective: Establish categories of risk for development of severe acute kidney injury based on the combination of levels uNGAL with various clinical variables. Material and methods: A clinical, retrospective, observational, descriptive and analytical study in the ICU of the Medica Sur Clinic Foundation in understood period of January 1, 2013 to December 31, 2014. Results: Eighty-two patients included in the study, 37 (45.1%) were male and 45 female (54.9%) with a mean age of 57 ± 20 years. The main cause of admission was septic shock in 57.3%. Creatinine levels and time uresis uNGAL significant differences with a probability less than 0.05. The cutoff for the diagnosis of acute kidney injury admission was 166.8 ng/mL, and the outcome of severe acute kidney injury, the income cutoff was 306.35 ng/mL. Conclusions: There was no statistically significant difference between variables except for the creatinine levels and urinary lipocalin uresis time. Cutting uNGAL admission to the outcome of severe AKI was 306.35 ng/mL.

Keywords : uNGAL; acute kidney injury; renal biomarker; renal replacement therapy.

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