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Salud Pública de México
Print version ISSN 0036-3634
Abstract
PARRA-COLIN, Paola De La et al. Association of high-risk human papillomavirus with ocular surface squamous neoplasia: a case-control study in Mexico. Salud pública Méx [online]. 2022, vol.64, n.2, pp.209-217. Epub Mar 13, 2023. ISSN 0036-3634. https://doi.org/10.21149/12796.
Objective:
To investigate the association of high-risk human papilloma virus (HR-HPV) and other risk factors with ocular surface squamous cell neoplasia (OSSN).
Materials and methods:
We obtained DNA from 22 fresh frozen OSSN tissues and 22 pterygia as controls, we used a broad-spectrum HPV DNA amplification short PCR fragment to identify HPV infection in all specimens and then genotyped HPV by a reverse hybridization line probe assay. We also obtained demographic, sun exposure, and tobacco consumption information.
Results:
HR-HPV frequency was 40.9% in the OSSN group and 4.5% in the pterygia group (p=0.009). After covariate adjustment, OSSN was associated with HR-HPV (OR=16.3, 95%CI=1.2,218.1, p=0.03) and sunburn (OR=10.8, 95%CI=1.8,86.0, p=0.02).
Conclusions:
Ocular surface squamous cell neoplasia is a multifactorial disease. The strong association between HR-HPV and OSSN, suggests that HR-HPV could play an etiological role in OSSN development.
Keywords : squamous cell neoplasms; human papillomavirus; conjunctiva; pterygium; sunburn.
