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Salud Pública de México
Print version ISSN 0036-3634
Abstract
GARCIA-MARTINEZ, Angélica et al. CYP1A1, CYP1B1, GSTM1 and GSTT1 genetic variants and breast cancer risk in Mexican women. Salud pública Méx [online]. 2017, vol.59, n.5, pp.540-547. ISSN 0036-3634. https://doi.org/10.21149/8527.
Objective:
To evaluate if variants in the genes CYP1A1 (T3801C and A4889G), CYP1B1 (G119T), GSTM1 (indel) and GSTT1 (indel) are associated with breast cancer (BC) among Mexican women.
Materials and methods:
952 incident cases with histologically confirmed BC were matched by age (± 5 years) and zone of residence with 998 healthy population controls. Genetic variants in genes CYP1A1, CYP1B1, GSTM1 and GSTT1were genotyped by allelic discrimination and multiplex PCR. In a subsample of women, 105 markers for ancestry were determined.
Results:
An increased BC risk, independent of other BC risk factors, was observed among carriers of CYP1B1 G119T genotype (T/T vs. G/G: OR=1.9; 95%CI 1.4-2.5).
Conclusion:
Our results support the existence of genetic susceptibility for BC conferred by CYP1B1 G119T variant among Mexican women.
Keywords : breast neoplasms; case-control studies; genetic susceptibility; Mexico.
