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Revista de investigación clínica
On-line version ISSN 2564-8896Print version ISSN 0034-8376
Abstract
MAGGIANI-AGUILERA, Pablo et al. The Sum of Kidney Donor Profile Index and Estimated Post-Transplant Survival Scale and Their Correlation with eGFR Decline in Deceased Donor Kidney Recipients. Rev. invest. clín. [online]. 2021, vol.73, n.4, pp.216-221. Epub Aug 23, 2021. ISSN 2564-8896. https://doi.org/10.24875/ric.20000618.
Background:
The impact of donor quality on post-kidney transplant survival may vary by candidate condition.
Objective:
Analyzing the combined use of the Kidney Donor Profile Index (KDPI) and the estimated post-transplant survival (EPTS) scale and their correlation with the estimated glomerular filtration rate (eGFR) decline in deceased-donor kidney recipients (DDKR).
Methods:
This was a retrospective, observational cohort study. We included DDKRs between 2015 and 2017 at a national third-level hospital.
Results:
We analyzed 68 DDKR. The mean age at transplant was 41 ± 14 years, 47 (69%) had sensitization events, 18 (26%) had delayed graft function, and 16 (23%) acute rejection. The graft survival at 12 and 36 months was 98.1% (95% CI 94-100) and 83.7% (95% CI 65-100), respectively. The Pearson correlation coefficient between the percentage reduction in the annual eGFR and the sum of EPTS and KDPI scales was r = 0.61, p < 0.001. The correlation coefficient between the percentage reduction in the annual eGFR and the EPTS and KDPI scales separately was r = 0.55, p < 0.001, and r = 0.53, p < 0.001, respectively.
Conclusions:
The sum of EPTS and KDPI scales can provide a better donor-recipient relationship and has a moderately positive correlation with the decrease in eGFR in DDKR.
Keywords : Kidney Donor Profile Index; Estimated post-transplant survival; Renal kidney graft survival; Deceased-donor kidney transplant; Estimate glomerular filtration rate; Graft loss.