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Gaceta médica de México
On-line version ISSN 2696-1288Print version ISSN 0016-3813
Abstract
DANTES-DURAN, Mayra A.; CASTELAN-MALDONADO, Edmundo E. and PALACIOS-SAUCEDO, Gerardo del C.. Association of high-grade prostatic intraepithelial neoplasia immunohistochemical profile with acinar adenocarcinoma of the prostate. Gac. Méd. Méx [online]. 2023, vol.159, n.2, pp.93-97. Epub Apr 24, 2023. ISSN 2696-1288. https://doi.org/10.24875/gmm.22000232.
Background:
Prostate carcinoma is the second leading cause of cancer and the fifth cause of cancer death in men worldwide.
Objective:
To know high-grade prostatic intraepithelial neoplasia and prostate acinar adenocarcinoma immunohistochemical profiles.
Material and methods:
Observational, analytical, cross-sectional, retrospective study of specimens obtained by cutting needle biopsy and prostate resection from subjects diagnosed with acinar adenocarcinoma of the prostate and high-grade prostatic intraepithelial neoplasia between January 2015 and December 2020. Tissue microarrays were performed and, subsequently, immunohistochemical studies for BCL2, EGFR, p53, Her2/neu and Ki67. Descriptive statistics were used to analyze clinicopathological factors. Qualitative variables were compared with Fisher's exact test.
Results:
Twenty-three patients were studied; eight (34%) with angiolymphatic invasion, 14 (60.8%) with perineural invasion, five (21.2%) with prostatitis, and four (17.3%) with fibroadenomatous hyperplasia. HER2/neu (p = 0.1023), p53 (p = 1) and BCL2 expression (p = 0.4136) was observed.
Conclusion:
HER2/neu increased expression was identified in high-grade prostatic intraepithelial neoplasia and acinar adenocarcinoma of the prostate.
Keywords : Acinar adenocarcinoma; Gleason; Intraepithelial prostatic neoplasia.