<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0187-5337</journal-id>
<journal-title><![CDATA[Perinatología y reproducción humana]]></journal-title>
<abbrev-journal-title><![CDATA[Perinatol. Reprod. Hum.]]></abbrev-journal-title>
<issn>0187-5337</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Perinatología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0187-53372025000100039</article-id>
<article-id pub-id-type="doi">10.24875/per.25000002</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[What is the master regulator of reproductive endocrinology? A sex-based functional review of the KISS1-KISS1R system]]></article-title>
<article-title xml:lang="es"><![CDATA[¿Cuál es el regulador principal de la endocrinología reproductiva? Una revisión funcional del sistema KISS1-KISS1R con perspectiva de género]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Okafor]]></surname>
<given-names><![CDATA[Izuchukwu A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nzoniwu]]></surname>
<given-names><![CDATA[Nnamdi A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Onyema]]></surname>
<given-names><![CDATA[Chikwesiri E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fakorede]]></surname>
<given-names><![CDATA[Sodiq]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,UMass Chan Medical School Division of Translational Anatomy Department of Radiology]]></institution>
<addr-line><![CDATA[Worcester ]]></addr-line>
<country>United States of America</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,College of Health Sciences, Nnamdi Azikiwe University Department of Anatomy Faculty of Basic Medical Sciences]]></institution>
<addr-line><![CDATA[Nnewi ]]></addr-line>
<country>Nigeria</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Abu Dhabi Vocational Education and Training Institute Applied Technology Schools Department of Biology]]></institution>
<addr-line><![CDATA[Al Ain ]]></addr-line>
<country>United Arab Emirates</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Nnamdi Azikiwe University College of Health Sciences Faculty of Basic Medical Sciences]]></institution>
<addr-line><![CDATA[Nnewi ]]></addr-line>
<country>Nigeria</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Federal University of Technology Department of Prosthetics and Orthotics ]]></institution>
<addr-line><![CDATA[Owerri ]]></addr-line>
<country>Nigeria</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2025</year>
</pub-date>
<volume>39</volume>
<numero>1</numero>
<fpage>39</fpage>
<lpage>49</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0187-53372025000100039&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0187-53372025000100039&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0187-53372025000100039&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Kisspeptin, a peptide encoded by the KISS1 gene, and its receptor, KISS1R, have emerged as pivotal regulators of reproductive endocrinology. This review explores the multifaceted roles of the KISS1-KISS1R system in both male and female reproduction, from puberty onset to gametogenesis, ovulation, pregnancy, and lactation. In males, kisspeptin influences spermatogenesis through intratesticular signaling, modulating steroidogenesis and sperm function. In females, it regulates follicular development, oocyte maturation, and ovulation by modulating gonadotropin release and ovarian signaling pathways. Beyond reproduction, kisspeptin has been implicated in metabolic regulation, energy balance, and reproductive behavior, highlighting its broader physiological significance. Recent studies suggest potential clinical applications, including its use as a biomarker for early pregnancy detection and as a therapeutic agent for infertility, polycystic ovary syndrome, and hyperprolactinemia. In addition, kisspeptin analogs have demonstrated promise in treating hormone-dependent malignancies, such as prostate cancer, by suppressing the hypothalamic-pituitary-gonadal axis. Compared to other reproductive hormones, kisspeptin stands out as an upstream regulator, directly controlling gonadotropin-releasing hormone secretion and the entire reproductive hormonal cascade. Given its central role, further research is warranted to elucidate its precise mechanisms and optimize its clinical applications. The KISS1-KISS1R system is undeniably a master regulator of reproductive endocrinology, presenting exciting opportunities for therapeutic advancements in reproductive medicine.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La kisspeptina, un péptido codificado por el gen KISS1, y su receptor, KISS1R, se han identificado como reguladores clave de la endocrinología reproductiva. Esta revisión explora los diversos roles del sistema KISS1-KISS1R en la reproducción masculina y femenina, desde el inicio de la pubertad hasta la gametogénesis, la ovulación, el embarazo y la lactancia. En los hombres, la kisspeptina influye en la espermatogénesis mediante la señalización intratesticular, modulando la esteroidogénesis y la función espermática. En las mujeres, regula el desarrollo folicular, la maduración del ovocito y la ovulación, modulando la liberación de gonadotropinas y las vías de señalización ovárica. Más allá de la reproducción, se ha implicado a la kisspeptina en la regulación metabólica, el balance energético y el comportamiento reproductivo, destacando su importancia fisiológica general. Los estudios recientes sugieren potenciales aplicaciones clínicas, incluyendo su uso como biomarcador para la detección temprana del embarazo y como agente terapéutico para la infertilidad, el síndrome de ovario poliquístico y la hiperprolactinemia. Además, los análogos de la kisspeptina se han mostrado prometedores en el tratamiento de neoplasias dependientes de hormonas, como el cáncer de próstata, al suprimir el eje hipotálamo-hipófisis-gónadas. Dado su papel central, se requiere más investigación para entender sus mecanismos precisos y mejorar sus aplicaciones clínicas. El sistema KISS1-KISS1R es, sin duda, un regulador principal de la endocrinología reproductiva, que ofrece emocionantes oportunidades para avances terapéuticos en medicina reproductiva.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Kisspeptin]]></kwd>
<kwd lng="en"><![CDATA[KISS1 gene]]></kwd>
<kwd lng="en"><![CDATA[KISS1R gene]]></kwd>
<kwd lng="en"><![CDATA[Human reproduction]]></kwd>
<kwd lng="en"><![CDATA[Reproductive physiology]]></kwd>
<kwd lng="en"><![CDATA[Molecular mechanisms]]></kwd>
<kwd lng="es"><![CDATA[Kisspeptina]]></kwd>
<kwd lng="es"><![CDATA[Gen KISS1]]></kwd>
<kwd lng="es"><![CDATA[Gen KISS1R]]></kwd>
<kwd lng="es"><![CDATA[Reproducción humana]]></kwd>
<kwd lng="es"><![CDATA[Fisiología reproductiva]]></kwd>
<kwd lng="es"><![CDATA[Mecanismos moleculares]]></kwd>
</kwd-group>
</article-meta>
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