SciELO Mexico - www.scielo.org.mx

SciELO Mexico - www.scielo.org.mx

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Ceftriaxone is third generation parenteral while cefaclor is second generation oral cephalosporin and have closely related chemical structures (Fig. 1). A number of experimental conditions were checked for their potential effect on the resolution of chromatographic peaks of the studied drugs. However, four experimental parameters, mobile phase composition, mobile phase flow rate, wavelength and pH were selected for thorough investigation of their effect on the separation of both the drugs.

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