Intente links en:Similares en:
In the literature a number of analytical methods have been reported for the determination of ceftriaxone and cefaclor in pharmaceutical formulation and biological samples. These include spectrophotometric [6-10], spectrofluorimetric [11-13], and chromatographic [14-24]. In the recent past the quality of drugs especially antibacterial agents has been compromised worldwide particularly in the developing countries. The easy availability of counterfeit/substandard drugs and the misuse of antibiotics have resulted in the development of resistant strains of microbes which is serious challenge for the health professionals. The aim of the present work is to develop a simple, sensitive, cost effect and time saving method for the simultaneous quantification of the two most frequently prescribed cepha-losporins in commercial formulations as well as in biological samples. The simultaneous quantification of the two important cephalosporins with isocratic solvent system in a single run not only saves the solvent but also with a short run time makes it a better choice for the analysis of these drugs in quality control and research laboratories. The proposed method was validated according to ICH guidelines and requires minimum preparation of sample with a well-resolved peaks without interferences.