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After the isolation of Cephalosporin C from fungus Cephalosporium Acremonium, in the early 1950s and its conversion to 7-aminocephalosporanic acid, a new group called cephalosporin was added to the arsenal of antibiotics. Five generation of this new group are currently in clinical use, all of which are semisynthetic antibacterial agents derived from the 7-ami-nocephalosporanic acid and belong to the β-lactam family of antibiotics. The cephalosporins have greater stability towards deactivation by β-lactamases as compared to other β-lactam antibiotics. Cephalosporins are available in both parenteral and oral form and are among the widely prescribed antibacterial group worldwide [1, 2].