Resumen

SEBASTIAN-DIAZ, Mario A. et al. Seizures in chronic kidney disease: etiology and approach. Arch. Neurocien. (Mex.) [online]. 2025, vol.30, n.1, pp.35-43.  Epub 14-Oct-2025. ISSN 2954-4122.  https://doi.org/10.24875/anc.m24000027.

Chronic kidney disease (CKD) is associated with high morbidity and mortality, decreased quality of life and economic repercussions. Neurological complications are diverse, despite advances in medical management, replacement therapies and kidney transplantation. The location of damage secondary to CKD may involve the central nervous system (CNS), the peripheral nervous system, and the autonomic nervous system. Cortical alterations include cognitive impairment, encephalopathy, dementia, asterixis, myoclonus, cerebral vascular events, and seizures. These are a frequent complication in CKD and their origin may be related to the underlying disease, due to a decrease in the glomerular filtration rate, hemodynamic, electrolyte, or hormonal disturbances, or because of renal replacement therapies. The management of seizures in CKD requires extensive knowledge of the pathophysiological aspects and early detection of the risk factors associated with their appearance. The main causes of seizures in kidney disease are uremic encephalopathy, dialysis imbalance syndrome, hydro electrolyte disorders, kidney transplant or associated with drugs. The appearance of seizures is a very common complication and requires a multidisciplinary approach between the different areas of medicine involved, especially neurology and nephrology.

Palabras llave : Epileptic seizures; Kidney; Chronic kidney disease; Central nervous system.

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