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Revista médica del Hospital General de México

versão On-line ISSN 2524-177Xversão impressa ISSN 0185-1063


ALCANTARA-VAZQUEZ, Avissai; CHAPA-AZUELA, Óscar; DIAZ-RODRIGUEZ, Luis  e  HERNANDEZ-GONZALEZ, Mercedes. Gastrointestinal stromal tumor: pathological and clinical characteristics in the population of the General Hospital of Mexico "Dr. Eduardo Liceaga". Rev. med. Hosp. Gen. Méx. [online]. 2019, vol.82, n.1, pp.4-10.  Epub 06-Set-2021. ISSN 2524-177X.

The gastrointestinal stromal tumors (GISTs) are neoplasms of mesenchymal origin; they represent 0.3% of neoplasm in the digestive tube. They are defined by the expression of CD117, a tyrosine kinase receptor of the growth factor. Our objective is to know the clinical, pathological, and immunohistochemical characteristics in the population who attend the general hospital of Mexico. The cases of mesenchymal tumors in the digestive system during the period of July 2010-May 2017 were revised. Fifty-four cases of GIST were found; in all cases, clinical data and the macroscopic aspect were studied, and microscopy and immunohistochemical characteristics were also checked. These cases are more frequent in women, in a proportion of 1.2:1, with an average age of 54-year-old. The treatment was full surgery, in 4 of them, a lymphadenectomy was done, and metastasis was found in one case. The average size of the tumors was 8 cm. The predominant histological pattern was fusocellular (81.5%), followed by epithelioid patterns (7.4%) and mixed (11.1%). The main locations were the stomach (48.1%), small intestine (40.7%), rectum (5.6%), omentum (3.7%), and mesentery (1.9%). The malignant potential according to Fletcher's criteria were very low malignant potential (20.5%), low malignant potential (25%), intermediate potential (20.5%), and high malignant potential (34.1%). All cases were positive for CD117.

Palavras-chave : Gastrointestinal stromal tumor; C-KIT; CD117.

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