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Cirugía y cirujanos
versão On-line ISSN 2444-054Xversão impressa ISSN 0009-7411
Resumo
PARRA-MARQUEZ, Miguel L. De la; PERALTA-ENRIQUEZ, Abril; PENA, Victor G. e CHARLES-LOZOYA, Sergio. Protective effect of nitroglycerin ointment and dimethyl sulfoxide on necrosis of skin flaps in rats. Cir. cir. [online]. 2023, vol.91, n.5, pp.596-600. Epub 30-Out-2023. ISSN 2444-054X. https://doi.org/10.24875/ciru.22000203.
Objective:
To compare the protective effect of nitroglycerin ointment 2% and Dimethylsulfoxide (DMSO) in dorsal flaps of the rat.
Methods:
A blind, experimental study was conducted in 24 male Wistar rats, with a mean weight of 320 (286-376) grams. Group 1: Control. Petrolatum jelly (Vaseline), n = 8, Group 2: Nitroglycerin (NTG) ointment 2% (Nitro-Bid, Altana Co.) n = 8, and Group 3: DMSO gel 90% (Neogen corp. Lexington KY, 40611), n = 8.
Results:
A total of 24 rats were operated on in the 6-month period of this study. Using a non-parametric Mann–Whitney U-test analysis, a statistically significant p was obtained between the control group and 2% NTG ointment, both in the area of necrosis and in the healthy area (p = 0.026). In contrast, the comparison between DMSO [CH3) 2SO] and the control group (p = 0.180) and between both study groups, with a p = 0.18, was not significant.
Conclusions:
Our study concluded that there is a protective effect of 2% NTG ointment for flap survival in relation to the control group (petrolatum). DMSO administered topically did not show a protective effect, compared to the control group.
Palavras-chave : Dimethyl sulfoxide; Nitroglycerin ointment; Flap necrosis.
