Case description:

Three pediatric patients with urethral stenosis due to multiple etiologies underwent mechanical Paclitaxel coated balloon dilation (Ranger TM). All of them underwent fluoroscopic follow-up at 3 months and no recurrence was observed.

Relevance:

The worldwide incidence of urethral stenosis in males is 0.2-0.6 %. Currently, urethroplasty is the best therapeutic option. Paclitaxel is an antiproliferative drug initially used as a chemotherapeutic agent and currently used for resolution of coronary obstruction due to the inhibition of fibroblast growth. We advocate for its use along with mechanical ballon dilation for the treatment of urethral stenosis.

Clinical implications:

Urethral Paclitaxel balloon dilation has shown better anatomic and functional results in anterior urethral stenosis compared with endoscopic treatment, specially in recurrent stenosis <3 cm in third fase studies. The short and medium term results are promising with a success rate of more than 65 %.

Conclusions:

Paclitaxel coated balloon dilation can be used safely in pediatric patients with urethral stenosis, achieving resolution of obstruction.

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