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Revista mexicana de ciencias farmacéuticas
versión impresa ISSN 1870-0195
Resumen
CRUZ TAMAYO, Paulina y VILLAFUERTE ROBLES, Leopoldo. Gelucire 39/01 as a matrix for controlled release of ranitidine hydrochloride from floating granules. Rev. mex. cienc. farm [online]. 2014, vol.45, n.3, pp.54-64. ISSN 1870-0195.
The application of Gelucire 39/01 for the design of floating granules of sustained-release is explored, using as a model drug ranitidine hydrochloride and different excipients to modulate the release profile. Increasing the proportion of Gelucire 39/01 decreases the release rate of the drug as well as the amount of drug released at the beginning, in an abrupt manner. The addition of different proportions of others excipients modify the release rate as well as the drug released in the initial burst. Gelucire 39/01 cannot be considered as a carrier for sustained release by itself. HPMC K15M, Tween 80, microcrystalline cellulose, Aerosil, and GalenIQ 720 allow the modulation of the release profile from the floating granules in a limited manner. All granules float individually or forming agglomerates.
Palabras llave : Sustained release; Dissolution profile; Granulation method; floating granules; Excipients effect; Gelucire 39/01.