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Revista mexicana de neurociencia
versión On-line ISSN 2604-6180versión impresa ISSN 1665-5044
Resumen
CERVANTES-ARRIAGA, Amin et al. Type 2 diabetes mellitus as a determinant factor for the age of Parkinson’s disease onset. Rev. mex. neurocienc. [online]. 2023, vol.24, n.1, pp.3-7. Epub 25-Ene-2023. ISSN 2604-6180. https://doi.org/10.24875/rmn.22000048.
Objective:
This study aims to identify whether type 2 diabetes mellitus (T2DM) impacts the age of Parkinson’s disease (PD) onset.
Methods:
Consecutive people living with PD (PwP) with 2-4 years of disease duration were included and categorized according to the presence of T2DM. A 2:1 ratio randomization from the non-DM sample was performed. T2DM diagnosis was defined by a positive personal history of T2DM recorded in the medical files or reported by the subject, or the use of a hypoglycemic drug for glycemic control. A clinical assessment including the Movement Disorder Society Unified Parkinson’s disease rating scale and the Hoehn and Yahr was performed by a movement disorders specialist.
Results:
One hundred and twenty-four non-T2DM PwP and 62 PwP with T2DM (PD-DM) were included in the study. No statistically significant differences between groups were found in motor and non-motor scores nor in disease duration. The mean age of the whole sample was 63.4 ± 11.9 years, with a mean PD duration of 3.4 ± 0.8 years. In the PD-DM group, the mean duration of T2DM was 12.4 ± 6.8 years, and T2DM was diagnosed 9.2 ± 6.8 years before the PD onset. The PD-DM group had an older age of PD onset (5.9 ± 1.6 year, p < 0.001).
Conclusions:
Patients with PD-DM had an older age at PD onset, suggesting a potential T2DM role in delaying the age of disease onset.
Palabras llave : Parkinson disease; Type 2 diabetes; mellitus; Age of onset; Risk factors.