SciELO - Scientific Electronic Library Online

vol.91 número8Índice de Robson: riesgo de cesárea en un centro de primer nivel en MéxicoFisiopatología de la programación fetal y su repercusión en la salud futura índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados




Links relacionados

  • Não possue artigos similaresSimilares em SciELO


Ginecología y obstetricia de México

versão impressa ISSN 0300-9041


RODRIGUEZ CRUZ, Didilia et al. Evaluation of the Pro12Ala polymorphism of the PPARƴ gene in women with gestational diabetes mellitus. Ginecol. obstet. Méx. [online]. 2023, vol.91, n.8, pp.581-587.  Epub 17-Nov-2023. ISSN 0300-9041.


To determine the frequency of peroxisomal proliferator-activated receptor gamma (PPARg) polymorphism of proline substituted with an alanine in amino acid 12 (Pro12Ala), in women with gestational diabetes mellitus and associate its impact with glycemia.


An ambispective, observational, cross-sectional and correlational study was carried out in a cohort of women with gestational diabetes that included 81 pregnant women treated at the Military Hospital for Women's Specialties and Neonatology of the Ministry of National Defense in the city from Mexico. Polymorphism was evaluated by amplification of a DNA fragment by PCR Polymerase Chain Reaction and its sequencing.


The results indicated that 13.5% of the women carriers of the Ala allele also had lower blood glucose values and a history with a higher number of abortions compared to women without the Ala allele.


The presence of the Ala allele in pregnant women with gestational diabetes mellitus could have a protective effect against hyperglycemia in pregnancy and a risk of abortion.

Palavras-chave : Gestational Diabetes Mellitus; PPARg; Pro12 Ala; Polymorphism.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )