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Ginecología y obstetricia de México

versão impressa ISSN 0300-9041


MARQUEZ IBARRA, Adriana Alejandra; MARISCAL RAMIREZ, Blanca Estela; GONZALEZ PONCE, Ana María  e  VALBUENA GREGORIO, Edith. Changes in the microbiota during pregnancy: a narrative review. Ginecol. obstet. Méx. [online]. 2023, vol.91, n.7, pp.499-515.  Epub 31-Out-2023. ISSN 0300-9041.


to evaluate the scientific evidence on changes in the microbiota during pregnancy.


A review of the literature published between 2013 and 2022 was carried out through the search of scientific articles in Spanish and English in the bibliographic databases NICE, CENETEC-SALUD, BIREME AND PORTAL WHO, PAHO, Portal of Evidence of the Virtual Health Library - BVS, LILACS, BIREME, EVIPNET, PUBMED and COCHRANE. The selection of articles was based on the descriptors: Microbiota, pregnancy, Gut microbiome, Fetus-Microbiota, Placenta - Microbiota, combined with each other with the Boolean “and”.


A total of 3,038 possible articles were identified and 137 were found suitable for the objective of the review because they were directly related to pregnancy and microbiota. Cross-sectional studies, trials, reviews, cohorts, case-controls, systematic review, or meta-analysis were reviewed.


Microbiota has been found in various tissues or organs that were previously believed to be sterile during pregnancy, and with this, it is suggested that all the changes that this stage entails can influence the maternal and fetal microbiota. However, despite the growing research in the area, there are still questions to be resolved to help solve the enigma of the changes in diversity in the different complications of pregnancy and whether the use of probiotics would influence reducing the risk to present them.

Palavras-chave : Gut microbiome; Fetus-Microbiota; Placenta; Gastrointestinal Microbiome; Probiotics; Infertility; Fetus.

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