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Ginecología y obstetricia de México

versión impresa ISSN 0300-9041


HERNANDEZ-MUNOZ, Eduardo Alfonso et al. Atypical congenital syphilis with a double negative VDRL from the mother. A case report. Ginecol. obstet. Méx. [online]. 2022, vol.90, n.11, pp.924-932.  Epub 27-Ene-2023. ISSN 0300-9041.


Syphilis is a sexually transmitted infection acquired through blood transfusion, by direct contact with an active lesion or by the vertical route. The infection can be transmitted to the fetus at any time during pregnancy. Each year, 749,000 cases of congenital syphilis are reported worldwide. In Mexico, from 2007 to 2017, 1030 cases of congenital syphilis were reported (average of 90.6 cases per year). In 50 to 80% of cases there are maternal-fetal complications.


To report a clinical case of early congenital syphilis with bullous pemphigus and desquamation at birth.


25-year-old patient, with a history of four pregnancies, two deliveries and one abortion, previously healthy, with prenatal control and negative VDRL and HIV tests. The last two pregnancies ended with a newborn, both female, with decapitated blistering lesions, whitish plaques of rough appearance raised on an erythematous base, erythema with thick desquamation on the hands and feet, and generalized fine desquamation. Suspecting congenital syphilis, 50,000 IU/kg of crystalline penicillin G intravenously every 12 h was started. The suspicion of congenital syphilis was confirmed. The patient was discharged with follow-up outpatient appointments.


Adequate prenatal screening, with one or two tests for syphilis, is not sufficient to prevent the congenital form. Case analysis is necessary to find options and implement public health strategies to prevent new cases.

Palabras llave : Syphilis, congenital; Blood transfusion; Pregnancy; Pemphigus; Prenatal diagnosis; Penicillin G; Erythema; Fetus.

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