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Ginecología y obstetricia de México

Print version ISSN 0300-9041


FRIAS-SANCHEZ, Zoraida et al. Invasive mola in 13-year-old girl. Fundamental aspects in diagnosis and treatment. Ginecol. obstet. Méx. [online]. 2020, vol.88, n.4, pp.252-260.  Epub Aug 30, 2021. ISSN 0300-9041.


Gestational trophoblastic neoplasia is a rare tumor that originates from pregnancy and it develop from anormal proliferation of trophoblastic tissue. It includes four varieties, including invasive mole and choriocarcinoma. They can present different degrees of proliferation, being essential differential diagnosis since it directly influences the treatment. Premalignant moles are usually treated by suction curettage while malignant forms require systemic therapy with mono or polychemotherapy.


Report the case, paying special attention to the differential diagnosis and treatment used, analyzing the reasons why polychemotherapy is established and describing the different possible options, based on current scientific evidence.


We present the case of an invasive mola in a 13-year-old patient hospitalized by vomiting and abdominal pain. During this period, complementary techniques such as the determination of the β fraction of the human chorionic gonadotropin (β-hCG) or computed tomography (CT) are required to establish the differential diagnosis. Finally, the definitive diagnosis is provided by the biopsy obtained by curettage. Treatment is instituted with the pattern of polychemotherapy being, currently, with complete remission of the disease.


Thus, it is essential to detect anomalous gestation early, to understand perfectly the evolution of this entity, the importance of contraception during its resolution, and to minimize patients susceptible to chemotherapy.

Keywords : Gestational trophoblastic neoplasia; Pregnancy; Proliferation; Invasive Mole; Choriocarcinoma; Polychemotherapy; Differential Diagnosis; Hydatidiform mole.

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