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Perinatología y reproducción humana

On-line version ISSN 2524-1710Print version ISSN 0187-5337


RODRIGUEZ-CABRERA, Ana F.; CARDENAS-DEL CASTILLO, Bárbara G.; ENRIQUEZ-BRICENO, Rita  and  NIETO-SANJUANERO, Adriana. Risk factors associated with extubation failure in premature patients in the neonatal intensive care unit. Perinatol. Reprod. Hum. [online]. 2023, vol.37, n.1, pp.11-17.  Epub June 05, 2023. ISSN 2524-1710.


In the neonatal intensive care unit, 47% of premature infants require mechanical ventilation (MV); its prolonged use is associated with long-term sequelae.


To identify the risk factors for extubation failure in premature infants.

Material and methods:

Case-control study, taking failed extubations (FE) as cases and successful extubations (SE) as controls. Extubation failure was defined as reintubation within the first 72 hours.


46% of hospitalized premature infants required MV; twelve FE and 27 SE were presented. The proportion of FE was 31%. MV over 7 days was 17% in cases and 11% in controls (OR: 0.6; 95% CI: 0.09-4.32; p = 0.634). The main cause of reintubation was apnea (50%).


The parameters established for this study were not determined as risk factors for failed extubation. Due to the case numbers in this study, we are unable to identify a good cut-off value for risk factors and predictors. More large-scale studies are required to confirm our findings and determine cut-off values.

Keywords : Prematurity; Extubation; Mechanical ventilation.

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