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Perinatología y reproducción humana

On-line version ISSN 2524-1710Print version ISSN 0187-5337


CARRERA-MUINOS, Sandra et al. Evolution of newborns with persistent pulmonary hypertension in a neonatal intensive care unit. Perinatol. Reprod. Hum. [online]. 2022, vol.36, n.2, pp.40-45.  Epub Dec 01, 2022. ISSN 2524-1710.


Persistent pulmonary hypertension (PPHN) occurs in 2 to 6 out of 1,000 live newborns, with mortality between 4 and 33%.


To learn the frequency, evolution and morbidity of the disease.

Material and method:

Of 71 patients the sample was divided into two groups, Group A: 44 (61.97%) surviving patients and Group B: 27 (38%) deceased. Standard percentages, averages and deviations were calculated, in addition to Student’s T, Square Chi and OR IC95%.


There was a significant difference in the weight of the groups, where surviving patients had greater birth weight. In 54.93% hypertension was primary and 45.07% secondary. Endotracheal intubation increased 1.2 times the risk of mortality, the use of polytherapy does not decrease the risk of mortality. Within complications 88.1% pulmonary dysplasia development, there was no difference in the presence of dysplasia.


PPHN was associated with high morbidity in newborns, survivors were more weight, intubation increased the risk of mortality, there were no differences in pharmacological therapy. 88% developed bronchopulmonary dysplasia. Mortality occurred at 38%.

Keywords : Persistent pulmonary hypertension; Mechanical ventilation; Respiratory failure.

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