Abstract

FLORES-ROJAS, Lupitha Elizabeth  and  GONZALEZ-ZUNIGA HERNANDEZ, Leticia Arely. Metabolic side effects of second-generation antipsychotics. Med. interna Méx. [online]. 2019, vol.35, n.5, pp.721-731.  Epub Apr 30, 2021. ISSN 0186-4866.  https://doi.org/10.24245/mim.v35i5.2658.

Antipsychotics are widely prescribed to treat a large number of neuropsychiatric problems. Antipsychotics are divided in two classes according to their chemical structure, typical or first generation and the atypical or second generation. The second-generation antipsychotics have greater benefits because they produce less extrapyramidal side effects; however, several studies in both humans and animals have related their administration to metabolic side effects, such as obesity, weight gain, diabetes, dyslipidemia, metabolic syndrome and insulin resistance. Because of the effects, clinical guidelines for the control and monitoring of patients with a treatment with these drugs have been established. The aim of this paper is to review some metabolic side effects produced by the second-generation antipsychotics and its possible mechanism of action, as well as the metabolic control or monitoring that patients treated with these drugs should have. The research of the articles was made in the databases: PubMed, EBSCOHOST, DynaMed and IntraMed.

Keywords : Atypical antipsychotic; Metabolic syndrome; Obesity; Insulin resistance; Diabetes; Hyperlipidemia.

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