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Salud mental

versão impressa ISSN 0185-3325

Resumo

AGUIRRE-HERNANDEZ, Eva et al. Anxiolytic and sedative-like effects of flavonoids from Tilia Americana var. Mexicana: GABAergic and serotonergic participation. Salud Ment [online]. 2016, vol.39, n.1, pp.37-46. ISSN 0185-3325.  https://doi.org/10.17711/SM.0185-3325.2015.066.

INTRODUCTION:

The inflorescences of Tilia americana var. mexicana are used as an infusion in Mexican traditional medicine due to their tranquilizing effects; however, pharmacological and phytochemical studies of the leaves are lacking.

OBJECTIVE:

In this research, the anxiolytic and sedative-like efficacy of the Tilia americana var. mexicana leaves was compared to that obtained with its inflorescences and flavonoids therein identified, as well as the possible mechanism of action.

METHODS:

The sorted and dried inflorescences and leaves were macerated subsequently in hexane, ethyl acetate and methanol. The methanol extracts were qualitative- and quantitative-analyzed by HPLC, using commercial flavonoids standards selected on the basis of their previously reported presence in Tilia species. The pharmacological activity was evaluated in CD-1 mice in the tests: open-field, elevated plus-maze, hole-board, and the sodium pentobarbital-induced sleep potentiation test. In regard to the mechanism of action, participation of benzodiazepine and 5-HT1A serotonin receptors was tested with the respective antagonists: flumazenil and WAY100635.

RESULTS:

The presence of quercetin, rutin and isoquercitrin was confirmed in the extracts of the inflorescences and leaves. The anxiolytic-like effects were the same between the two organs, which were inhibited in the presence of flumazenil and WAY100635.

DISCUSSION AND CONCLUSION:

Our results provide evidence that the extracts of the leaves of T. americana var. mexicana are as efficacious as the inflorescences to produce anxiolytic and sedative-like effects, where flavonoids like quercetin, rutin and isoquercitrin are partially responsible for these activities by the involvement of GABA/BDZ and 5HT1A serotonergic receptors.

Palavras-chave : Anxiety; isoquercitrin; quercetin; rutin; sedative; Tilia.

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