Abstract

LOPEZ-ORDONEZ, Teresa et al. Genomic and proteomic contributions for Chagas disease control. Salud pública Méx [online]. 2009, vol.51, suppl.3, pp.s410-s423. ISSN 0036-3634.

Chagas disease represents one of the more significant public health problems in the Americas. Information regarding the genome and proteome of vectors and parasite, as well as their interactions, will be essential to develop specific and effective diagnostic and preventive tools. Advances that have contributed to the design, implementation, and efficacy of disease surveillance and control activities are reviewed. Genomic and proteomic information has contributed to a better understanding of vector distributions and dispersion, diversity, population dynamics, and control targets (populations and species). In addition, genomic and proteomic studies have impacted parasite diagnostics, Trypanosoma cruzi population dynamics, pharmacological treatment and knowledge of parasite-host interactions. Discussion of these contributions includes expectations for future basic and applied research questions.

Keywords : Chagas disease; Triatominae; Trypanosoma cruzi.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )