SciELO - Scientific Electronic Library Online

vol.46 issue4Nitazoxanide vs albendazole against intestinal parasites in a single dose and for three days author indexsubject indexsearch form
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • Have no similar articlesSimilars in SciELO


Salud Pública de México

Print version ISSN 0036-3634


GALVEZ-GASTELUM, Francisco Javier; SANDOVAL-RODRIGUEZ, Ana Soledad  and  ARMENDARIZ-BORUNDA, Juan. Transforming growth factor-b as a therapeutic target. Salud pública Méx [online]. 2004, vol.46, n.4, pp.341-350. ISSN 0036-3634.

Transforming growth factor-b (TGF-b) family members include TGF-b, activins, and bone morphogenetic proteins (BMP). These proteins are structurally related cytokines secreted in diverse Metazoans. TGF-b family members regulate cellular functions such as proliferation, apoptosis, differentiation, and migration, and play an important role in organism development. Deregulated TGF-b family signaling participates in various human pathologies including auto-immune diseases, vascular disorders, fibrotic disease, and cancer. Ligand-induced activation of TGF-b family receptors with intrinsic serine/threonine kinase activity, triggers phosphorylation of the intracellular effectors of TGF-b signaling, the Smads proteins. Once these proteins are activated they translocate into the nucleus, where they induce transcription of target genes and regulate cellular processes and functions. Novel therapeutic strategies are currently being developed to correct alterations in pathologies that involve TGF-b as the main mediator.

Keywords : signal transduction; transforming grouth factor beta; smad; receptor.

        · abstract in Spanish     · text in Spanish


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License