Resumo

ZHAO, Shaofei; YANG, Qian  e  GAO, Changjun. The Mechanism of Super-enhancer Regulation Of Gene Expression And Research Progress in Neurodegenerative Diseases. Rev. invest. clín. [online]. 2025, vol.77, n.2, pp.35-43.  Epub 05-Ago-2025. ISSN 2564-8896.  https://doi.org/10.24875/ric.24000246.

Super-enhancers (SEs) play a key role in cell fate determination by regulating the transcription of cell-specific target genes and may contribute to the pathogenesis of neurodegenerative diseases. Targeted inhibition of the activity of SEs or knockout of SEs fragments may represent a novel therapeutic strategy for neurodegenerative diseases. This article mainly outlines the discovery, structure, and identification methods of SEs; lists the current SE database platforms; summarizes the main regulatory mechanisms of SEs and strategies to acquire disease-specific SEs; and reviews recent research advances on SEs in neurodegenerative diseases. These findings provide new insights into the molecular mechanisms and development of treatment for neurodegenerative diseases. (REV INVEST CLIN. 2025;77(2):35-43)

Palavras-chave : Enhancer; Super-enhancers; Alzheimer's disease; Parkinson's disease; Huntington's disease.

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