SciELO - Scientific Electronic Library Online

vol.73 número4Type 1 Diabetes Care in Mexico: An Analysis of the RENACED-DT1 National RegistryShort- and Mid- Term Impact of Tobacco Smoking on Donor Renal Function Following Living Kidney Donation at a Tertiary Referral Hospital índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados

  • No hay artículos similaresSimilares en SciELO


Revista de investigación clínica

versión On-line ISSN 2564-8896versión impresa ISSN 0034-8376


SOLIS-ARMENTA, Rubén; CACHO-DIAZ, Bernardo; GUTIERREZ-HERNANDEZ, Olga  y  CANDELARIA-HERNANDEZ, Myrna. Central Nervous System International Prognostic Index Impacts Overall Survival in Diffuse Large B-cell Lymphoma Treated with R-Chop in a third Level Cancer Center from Mexico: A Survey of 642 Patients. Rev. invest. clín. [online]. 2021, vol.73, n.4, pp.231-237.  Epub 23-Ago-2021. ISSN 2564-8896.


Central nervous system international prognosis index (CNS-IPI) is validated in European and the USA cancer databases. However, no validation has been done in Mexican population.


The objective of the study was to assess the impact of the CNS-IPI on central nervous system (CNS) relapse and survival in Mexican patients with diffuse large B-cell lymphoma (DLBCL).


In this retrospective analysis, clinical, biochemical, and histological variables and the CNS-IPI were analyzed.


Six hundred and forty-two patients with DBLCL were included in the study. The mean ± SD age was 56.8 ± 14.9 years. Most had an ECOG of 0-1: 75% (n = 484) had absence of B-symptoms and advanced disease (clinical stage: III-IV, n = 433, 67.4%). According to the CNS-IPI, almost one-half were in the low-risk category. According to the CNS-IPI, CNS relapse rate was 1.36% (95% CI: 83.2-92.8), 3.1% (95% CI: 132.4-162.8), and 7.4% (95% CI 61-91) for patients in the low-, intermediate-, and high-risk categories, respectively. The median overall survival in the high-risk group (CNS-IPI) was 22 months, and it has not been achieved after 80 months of follow-up for the other groups.


CNS-IPI was associated with survival; therefore, we propose its use as a prognostic tool for prospective validation.

Palabras llave : Diffuse large B-cell lymphoma; Central nervous system relapse; Prognosis; Survival; Central Nervous System International Prognosis Index.

        · texto en Inglés     · Inglés ( pdf )