SciELO - Scientific Electronic Library Online

vol.73 número4Surge in Ventilator-Associated Pneumonias and Bloodstream Infections in An Academic Referral Center Converted to Treat COVID-19 Patients índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados

  • No hay artículos similaresSimilares en SciELO


Revista de investigación clínica

versión On-line ISSN 2564-8896versión impresa ISSN 0034-8376


DIAZ, Lorenza et al. Ethical Considerations in Animal Research: The Principle of 3R's. Rev. invest. clín. [online]. 2021, vol.73, n.4, pp.199-209.  Epub 23-Ago-2021. ISSN 2564-8896.

In the last century, progress in the knowledge of human diseases, their diagnosis and treatment have grown exponentially, due in large part to the introduction and use of laboratory animals. Along with this important progress, the need to provide training and guidance to the scientific community in all aspects related to the proper use of experimental animals has been indispensable. Animal research committees play a primary role in evaluating experimental research protocols, from their feasibility to the rational use of animals, but above all in seeking animal welfare. The Institutional Committee for the Care and Use of Animals (IACUC) has endeavored to share several relevant aspects in conducting research with laboratory animals. Here, we present and discuss the topics that we consider of utmost importance to take in the account during the design of any experimental research protocol, so we invite researchers, technicians, and undergraduate and graduate students to dive into the fascinating subject of proper animal care and use for experimentation. The main intention of these contributions is to sensitize users of laboratory animals for the proper and rational use of them in experimental research, as well as to disseminate the permitted and unpermitted procedures in laboratory animals. In the first part, the significance of experimental research, the main functions of IACUC, and the principle of the three R’s (replacement, reduction, and refinement) are addressed.

Palabras llave : Institutional Animal Care and Use Committee; Reduction; Refinement; Replacement.

        · texto en Inglés     · Inglés ( pdf )