SciELO - Scientific Electronic Library Online

vol.72 número1Neutrophil Scattering Data Driven Pre-Microscopic Flagging of Acute Leukemic Cases índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados




Links relacionados

  • Não possue artigos similaresSimilares em SciELO


Revista de investigación clínica

versão On-line ISSN 2564-8896versão impressa ISSN 0034-8376


FENG, Ji-Feng; WANG, Liang; JIANG, You-Hua  e  YANG, Xun. A Novel Prognostic Index in Patients with Resectable Esophageal Squamous Cell Carcinoma: Fibrinogen/Prealbumin Ratio. Rev. invest. clín. [online]. 2020, vol.72, n.1, pp.46-54.  Epub 04-Maio-2021. ISSN 2564-8896.


Fibrinogen (Fib) to albumin (ALB) fibrinogen-to-albumin ratio as a prognostic index for esophageal cancer has been confirmed. A novel prognostic index was initially proposed with fibrinogen to prealbumin ratio (FPR) in patients with resectable esophageal squamous cell carcinoma (ESCC).


The objective of the study was to study the prognostic role of the novel prognostic index (FPR) in patients with resectable ESCC without any neoadjuvant treatment.


In this retrospective study, a total of 372 resectable ESCC patients without any neoadjuvant treatment were included. The best cutoff values were selected by the receiver operating characteristic curves. Two Cox regression analyses with forward stepwise (one for categorical variables and the other for continuous variables) were used to evaluate the overall survival (OS) and cancer-specific survival (CSS).


The best cutoff point was 0.014 for FPR. Patients with lower levels of FPR (≤0.014) had better CSS (50.7% vs. 18.0%, p < 0.001) and OS (48.0% vs. 17.6%, p < 0.001) than patients with higher levels of FPR (> 0.014). Multivariate Cox analyses (categorical and continuous) demonstrated that FPR was an independent prognostic factor in CSS (categorical: hazard ratio [HR]: 2.014, 95% confidence interval [CI]: 1.504-2.697, p < 0.001; continuous per 0.01: HR: 1.438, 95% CI: 1.154-1.793, p = 0.001) and OS (categorical: HR: 1.964, 95% CI: 1.475-2.617, p < 0.001; continuous per 0.01: HR: 1.429, 95% CI: 1.146-1.781, p = 0.002).


Our study indicated that FPR served as an independent prognostic factor in patients with resectable ESCC.

Palavras-chave : Esophageal squamous cell carcinoma; Fibrinogen; Albumin; Prealbumin; Cancer-specific survival; Overall survival; Prognosis.

        · texto em Inglês     · Inglês ( pdf )