SciELO - Scientific Electronic Library Online

vol.72 número1Hereditary Pituitary Tumor Syndromes: Genetic and Clinical AspectsReducing Length of Stay and Improving Quality of Care by Implementation of Informatics System and Care Bundle in the Intensive Care Unit índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados

  • No hay artículos similaresSimilares en SciELO


Revista de investigación clínica

versión On-line ISSN 2564-8896versión impresa ISSN 0034-8376


RAMIREZ-BELLO, Julian et al. The Branched-chain Amino Acid Transaminase 1 -23C/G Polymorphism Confers Protection Against Acute Coronary Syndrome. Rev. invest. clín. [online]. 2020, vol.72, n.1, pp.19-24.  Epub 04-Mayo-2021. ISSN 2564-8896.


Previous studies have shown an association between polymorphisms of the BAT1-NF-κB inhibitor-like-1 (NFKBIL1)-LTA genomic region and susceptibility to myocardial infarction and acute coronary syndrome (ACS).


The objective of the study was to study the role of three polymorphisms in the BAT1, NFKBIL1, and LTA genes on the susceptibility or protection against ACS; we included a group of cases-controls from Central Mexico.


The BAT1 rs2239527C/G, NFKBIL1 rs2071592T/A, and LTA rs1800683G/A polymorphisms were genotyped using a 5’ TaqMan assay in a group of 625 patients with ACS and 617 healthy controls.


Under a recessive model, the BAT1 -23C/G (rs2239527) polymorphism showed an association with protection against ACS (odds ratio = 0.56, and p-corrected = 0.019). In contrast, the genotype and allele frequencies of the NFKBIL1 rs2071592T/A and LTA rs1800683G/A polymorphisms were similar between ACS patients and controls and no association was identified.


Our data suggest an association between the BAT1 -23C/G polymorphism and protection against ACS in Mexican patients.

Palabras llave : Acute coronary syndrome; BAT; Single-nucleotide polymorphism.

        · texto en Inglés     · Inglés ( pdf )