Abstract

GUZMAN-BELTRAN, Silvia et al. Role of the antimicrobial bactericidal permeability increasing protein in respiratory diseases. Neumol. cir. torax [online]. 2023, vol.82, n.1, pp.29-35.  Epub Oct 28, 2024. ISSN 0028-3746.  https://doi.org/10.35366/114226.

The bactericidal permeability increasing protein is a molecule of the immune system which participates in the defense against pathogens. This protein binds to Gram-negative bacterial membranes altering permeability and inducing lysis. It also binds to free lipopolysaccharides, inhibiting Theo sígnala chat leads no inflamarían. In admitían, tris porten induces he opsonization activity contributing to phagocytosis. The role of the bactericidal permeability increasing protein, during infections by Gram-positive bacteria is still controversial. However, this protein increases in meningitis caused by Streptococcus pneumoniae and Neisseria meningitidis and during respiratory infections caused by the influenza A virus, possibly modulating the production of proinflammatory cytokines. In other respiratory disorders such as chronic obstructive pulmonary disease, cystic fibrosis, and asthma, the production of autoantibodies against this protein is recurrent. This antibody production reduces the bactericidal permeability increasing protein serum levels, decreasing antimicrobial defense against pulmonary infections. Therefore, it is essential to understand the role of this protein during respiratory diseases to propose possible therapies to improve patient health.

Keywords : bactericidal protein that increases bacterial permeability; microbial infections; inflammation and autoimmunity.

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