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Neumología y cirugía de tórax

Print version ISSN 0028-3746


SANCHEZ-RIOS, Carla Paola et al. EGFR mutations in pulmonary adenocarcinoma in smoking and non-smoking patients. Neumol. cir. torax [online]. 2018, vol.77, n.2, pp.137-144. ISSN 0028-3746.


The most widely used and reliable marker for the selection of patients candidates for treatment with tyrosine kinase inhibitors is the detection of mutations in exons 19 to 21 of the EGFR gene. The behavior of these mutations depends on the exposure factor and this has prognostic implications.


To evaluate the epidemiological profile of EGFR mutations in lung adenocarcinoma in smokers and non-smokers exposed to wood smoke at INER.

Material and methods:

An observational, retrospective and cross-sectional study was conducted at INER, Mexico City. We included patients with a diagnosis of pulmonary adenocarcinoma in the period from June 2013 to December 2016. Qualitative variables (gender, occupation, biomass exposure, histological pattern of adenocarcinoma, degree of histological differentiation, clinical stage, presence of metastasis, Gene EGFR) and quantitative (age, smoking, exposure to wood smoke). The analysis was performed in terms of absolute and relative frequencies as well as measures of central tendency.


A total sample of 252 patients was analyzed, 58.33% female and 41.67%. Of the male sex. EGFR mutation was identified in 32.5%. It was found that the most frequently mutated exon in both sexes was the 19 with differences in histological pattern in relation to the exposition factor.


The characterization of molecular profiles is an extremely useful tool in the presentation of therapeutic offers in non-small cell lung cancer. This is of interest since, like the histological pattern has a prognostic implication.

Keywords : Pulmonary adenocarcinoma; EGFR; prognosis.

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